Taniguchi Masatoshi, Nagai Koji, Watanabe Masato, Nimura Nami, Suzuki Ken-ichi, Tanaka Akihiro
Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Ibaraki, Japan.
J Antibiot (Tokyo). 2002 Jan;55(1):30-5. doi: 10.7164/antibiotics.55.30.
A novel benz[a]anthraquinone, YM-181741, was isolated from the culture broth of actinomycete strain Q57219. The strain was identified as Streptomyces sp. by morphological and chemotaxonomic characterization. YM-181741 was purified from the culture supernatant by serial column chromatography. The structure of YM-181741 was determined by spectroscopic analysis including one- and two-dimensional NMR experiments. YM-181741 showed selective anti-Helicobacterpylori activity with a MIC value of 0.2 microg/ml.
从放线菌菌株Q57219的培养液中分离出一种新型苯并[a]蒽醌，即YM-181741。通过形态学和化学分类学特征鉴定该菌株为链霉菌属。通过连续柱色谱法从培养上清液中纯化出YM-181741。通过包括一维和二维核磁共振实验在内的光谱分析确定了YM-181741的结构。YM-181741显示出对幽门螺杆菌的选择性抗菌活性，最低抑菌浓度值为0.2微克/毫升。
