来自头序棘豆块根的抗菌聚酮杂二聚体。
Antibacterial Polyketide Heterodimers from Pyrenacantha kaurabassana Tubers.
机构信息
†Equipe Recherche et Innovation en Chimie Médicinale, UMR INRA 1282 Infectiologie et Santé Publique, Université de Tours François Rabelais, 37200 Tours, France.
‡Laboratoire Inflammation, Tissus Epithéliaux et Cytokines EA4331, Université de Poitiers, 86022 Poitiers, France.
出版信息
J Nat Prod. 2015 Apr 24;78(4):597-603. doi: 10.1021/np5003252. Epub 2015 Mar 10.
Two heterodimers comprising anthraquinone and methylbenzoisocoumarin moieties (1 and 2) were isolated, together with emodin and physcion from the tubers of Pyrenacantha kaurabassana. The structures of 1 and 2 were established by NMR spectroscopy, including the analysis of a 2D INADEQUATE spectrum. On the basis of the data obtained, the structures that were previously proposed in the literature for these compounds were revised. Compounds 1 and 2 showed antibacterial activity against three different strains of Staphylococcus aureus. Compound 2 also showed bactericidal activity against Helicobacter pylori.
两种包含蒽醌和甲基苯并异香豆素部分的杂二聚体（1 和 2）与大黄素和大黄素从 Pyrenacantha kaurabassana 的块茎中分离出来。通过 NMR 光谱，包括 2D INADEQUATE 光谱的分析，确定了 1 和 2 的结构。根据获得的数据，对文献中这些化合物的结构进行了修正。化合物 1 和 2 对三种不同的金黄色葡萄球菌菌株表现出抗菌活性。化合物 2 对幽门螺旋杆菌也具有杀菌活性。
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