二氧霉素，一种新型苯并[a]蒽醌类抗生素。

Dioxamycin, a new benz[a]anthraquinone antibiotic.

作者信息

Sawa R, Matsuda N, Uchida T, Ikeda T, Sawa T, Naganawa H, Hamada M, Takeuchi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Apr;44(4):396-402. doi: 10.7164/antibiotics.44.396.

DOI:10.7164/antibiotics.44.396

PMID:2032948

Abstract

A new antibiotic, dioxamycin (1) was isolated from the culture broth of the strain MH406-SF1, which was closely related to Streptomyces xantholiticus. This antibiotic was purified by countercurrent chromatography, column chromatography and preparative HPLC. The molecular formula of 1 was determined to be C38H40O15 by HRFAB-MS. The structure was determined by spectral analysis of 2D NMR; 1H-1H COSY, 13C-1H COSY, long range 13C-1H COSY (HMBC) and NOESY. The antibiotic is active in vitro against Gram-positive bacteria and some tumor cells. Dioxamycin is a benz[a]anthraquinone antibiotic related to capoamycin.

摘要

一种新的抗生素——二氧霉素（1），是从与黄褐链霉菌密切相关的MH406-SF1菌株的培养液中分离得到的。该抗生素通过逆流色谱法、柱色谱法和制备型高效液相色谱法进行纯化。通过高分辨快原子轰击质谱（HRFAB-MS）确定1的分子式为C38H40O15。通过二维核磁共振光谱分析（1H-1H COSY、13C-1H COSY、远程13C-1H COSY（HMBC）和NOESY）确定其结构。该抗生素在体外对革兰氏阳性菌和一些肿瘤细胞具有活性。二氧霉素是一种与卡泊霉素相关的苯并[a]蒽醌类抗生素。