关于外用丙酸氯倍他索（得肤宝）全身效应的观察
Observations on the systemic effect of topical clobetasol propionate (Dermovate).
作者信息
Carruthers J A, August P J, Staughton R C
出版信息
Br Med J. 1975 Oct 25;4(5990):203-4. doi: 10.1136/bmj.4.5990.203.
Abstract
Topical application of clobetasol propionate in a strength of 0-05% in cream or ointment (Dermovate) suppressed the hypothalamic-pituitary-adrenal axis in both normal people and patients with diseased skin. In normal people the 9 am serum cortisol level was suppressed when between 45 and 90 g was applied weekly. Insulin stress test results in patients with diseased skin showed an abnormally small response after long-term application of similar amounts. We conclude that long-term administration should be restricted to less than 50 g a week.
摘要
以0.05%的丙酸氯倍他索乳膏或软膏（得肤宝）局部应用，会抑制正常人和皮肤病患者的下丘脑-垂体-肾上腺轴。在正常人中，每周涂抹45至90微克时，上午9点的血清皮质醇水平会受到抑制。皮肤病患者的胰岛素应激试验结果显示，长期应用相似剂量后反应异常小。我们得出结论，长期用药应限制在每周50微克以下。
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