Shigenobu Kazue, Ikeda Manabu, Fukuhara Ryuji, Maki Naruhiko, Hokoishi Kazuhiko, Nebu Akihiko, Komori Kenjiro, Tanabe Hirotaka
Department of Neuropsychiatry, Ehime University School of Medicine, Shigenobu-chou, Onsen-gun, Ehime, Japan 791-0295.
Int J Geriatr Psychiatry. 2002 Mar;17(3):211-7. doi: 10.1002/gps.551.
Delusions of theft (delusions involving the theft of possessions) are one of the most frequent neuropsychiatric manifestations of Alzheimer's disease (AD).
The current study investigated the presence and extent of such delusions before and after drug treatment in a group of AD patients, and the consequent effects on the burden of care on caregivers.
The study was an open-label cohort design. The delusions studied consisted only of those involving theft of possessions. Sixteen AD patients served as subjects in order to assess the efficacy of Risperidone administration, in the reduction or elimination of these delusions. The caregiver burden was evaluated using the Zarit Caregiver Burden Interview (ZBI) before the administration of Risperidone and 12 weeks after administration, for cases where delusions of theft were eliminated or reduced.
The burden of care on caregivers was significantly reduced (p < 0.001) through the elimination or reduction of delusions of theft.
Delusions of theft are considered to be a major factor in increasing the burden of care, and the treatment of these, through appropriate drug therapy, is therefore of great importance in the continuation of satisfactory care in the home.
盗窃妄想（涉及财物被盗的妄想）是阿尔茨海默病（AD）最常见的神经精神症状之一。
本研究调查了一组AD患者在药物治疗前后此类妄想的存在情况和程度，以及对照顾者护理负担的后续影响。
本研究采用开放标签队列设计。所研究的妄想仅包括涉及财物被盗的妄想。16名AD患者作为受试者，以评估利培酮给药在减少或消除这些妄想方面的疗效。在给予利培酮之前以及给药12周后（对于盗窃妄想已消除或减轻的病例），使用 Zarit 照顾者负担访谈量表（ZBI）评估照顾者负担。
通过消除或减轻盗窃妄想，照顾者的护理负担显著降低（p < 0.001）。
盗窃妄想被认为是增加护理负担的一个主要因素，因此通过适当的药物治疗来治疗这些妄想，对于在家中持续提供令人满意的护理非常重要。
