Stone Patrick
Palliative Medicine, St George's Hospital Medical School, London, UK.
Int J Palliat Nurs. 2002 Mar;8(3):120-8. doi: 10.12968/ijpn.2002.8.3.10248.
A review of research into cancer-related fatigue undertaken since 1995 is presented. The manner in which such fatigue varies with cancer diagnosis, stage of disease and anti-cancer treatment is discussed, and the causes of cancer-related fatigue are categorized according to whether they are cancer-specific, common to other chronic illnesses or common to the general population. Interventions to alleviate fatigue are discussed in terms of whether they are pharmacological or non-pharmacological in nature. It is concluded that cancer-related fatigue is a common problem with a major impact on quality of life. It shares a common aetiology with other forms of fatigue. Graded aerobic exercise has been shown in randomized controlled trials to be an effective intervention in specific patient groups. Less direct evidence supports the use of psychological interventions, but there is very little evidence to support the use of pharmacological treatment, with the possible exception of erythropoietin therapy for anaemic patients undergoing chemotherapy.
本文对1995年以来开展的癌症相关疲劳研究进行了综述。讨论了这种疲劳随癌症诊断、疾病阶段和抗癌治疗的变化方式，并根据与癌症相关的疲劳是癌症特异性的、其他慢性病共有的还是普通人群共有的，对其病因进行了分类。从本质上是药物性还是非药物性的角度，讨论了缓解疲劳的干预措施。得出的结论是，癌症相关疲劳是一个常见问题，对生活质量有重大影响。它与其他形式的疲劳有共同的病因。随机对照试验表明，分级有氧运动对特定患者群体是一种有效的干预措施。支持使用心理干预的直接证据较少，但几乎没有证据支持使用药物治疗，接受化疗的贫血患者使用促红细胞生成素治疗可能是个例外。
