Rittler Mônica, Castilla Eduardo E
Estudio Colaborativo Latinoamericano de Malformaciones Congénitas, Hospital Materno Infantil Ramon Sardá, Buenos Aires, Argentina.
Cad Saude Publica. 2002 Mar-Apr;18(2):421-8. doi: 10.1590/s0102-311x2002000200006. Epub 2002 Aug 16.
The specialized literature was reviewed concerning the suspected increasing secular trends in the frequency of female births, male genital congenital anomalies, abnormal sperm counts, and testicular cancer. Although no risk factors could be identified yet, the observed sex ratio decline during the last decades has been considered to be an effect of certain pollutants on normal hormone activity, and human reproductive development. Reported increasing trends in the frequencies of hypospadias and cryptorchidism are very difficult to be interpreted due to the large variability in the registered frequency of these malformations due to operational as well as biological reasons.
针对女性出生频率、男性生殖器先天性异常、精子计数异常和睾丸癌疑似存在的长期上升趋势，对专业文献进行了综述。尽管尚未确定风险因素，但过去几十年观察到的性别比例下降被认为是某些污染物对正常激素活性和人类生殖发育产生影响的结果。由于手术及生物学原因导致这些畸形登记频率存在很大差异，因此很难解释所报道的尿道下裂和隐睾症频率上升趋势。
