Wannier Th, Liu J, Morel A, Jouffrais C, Rouiller E M
Institute of Physiology and Program in Neurosciences, University of Fribourg, Switzerland.
Neuroreport. 2002 Jan 21;13(1):143-7. doi: 10.1097/00001756-200201210-00033.
To assess whether striatal and pallidal neurones may contribute to bimanual co-ordination, two macaque monkeys were trained to perform a delayed conditional sequence of co-ordinated pull and grasp movements, executed either bimanually or unimanually. Most of the 58 task-related neurones, recorded from the caudate nucleus, putamen, external and internal divisions of the globus pallidus, exhibited an activity related to the execution of the movements. Only a quarter of neurones displayed preparatory activity. The majority of units exhibited a significant modulation of activity in unimanual trials irrespective of the hand used to perform the task. In bimanual trials, one-third of units exhibited discharge patterns reflecting a bimanual synergy, suggesting a possible role for basal ganglia in inter-limb co-operation.
为了评估纹状体和苍白球神经元是否有助于双手协调，训练了两只猕猴执行一系列延迟的条件性协调拉和抓握动作，这些动作可以双手执行，也可以单手执行。从尾状核、壳核、苍白球的外部和内部区域记录的58个与任务相关的神经元中，大多数表现出与动作执行相关的活动。只有四分之一的神经元表现出准备活动。无论使用哪只手执行任务，大多数神经元在单手试验中都表现出显著的活动调节。在双手试验中，三分之一的神经元表现出反映双手协同作用的放电模式，这表明基底神经节在肢体间合作中可能发挥作用。
