Kemner Chantal, Oranje Bob, Verbaten Marinus N, van Engeland Herman
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands.
J Clin Psychiatry. 2002 Mar;63(3):214-7. doi: 10.4088/jcp.v63n0307.
An important characteristic of children with autism is their unusual reaction to stimuli, which may be related to problems in the filtering of sensory input. For this reason, sensory filtering was measured in children with autism using the P50 gating paradigm.
Twelve non-mentally retarded children with autism (i.e., having a DSM-IV diagnosis of either autistic disorder or pervasive developmental disorder not otherwise specified) and 11 healthy control children were tested for their ability to suppress P50, measured at the Cz electrode.
No differences were found between the children with autism and the control children with regard to absolute P50 amplitudes and P50 suppression.
The excitability of the neuronal substrate that causes P50 is normal in children with autism, as are the early, inhibitory processes related to P50 gating. These results distinguish between subjects with autism and subjects with schizophrenia, in whom sensory gating is abnormal.
自闭症儿童的一个重要特征是他们对刺激的异常反应，这可能与感觉输入过滤方面的问题有关。因此，使用P50门控范式对自闭症儿童的感觉过滤进行了测量。
对12名无智力障碍的自闭症儿童（即根据《精神疾病诊断与统计手册》第四版诊断为自闭症谱系障碍或未特定的广泛性发育障碍）和11名健康对照儿童进行测试，测量他们在Cz电极处抑制P50的能力。
自闭症儿童与对照儿童在绝对P50波幅和P50抑制方面未发现差异。
导致P50的神经元底物的兴奋性在自闭症儿童中是正常的，与P50门控相关的早期抑制过程也是正常的。这些结果区分了自闭症患者和精神分裂症患者，后者的感觉门控是异常的。
