Madsen Gitte Falcher, Bilenberg Niels, Jepsen Jens Richardt, Glenthøj Birte, Cantio Cathriona, Oranje Bob
From the Department of Child and Adolescent Mental Health Odense, Research Unit (University function), Mental Health Services in Region of Southern Denmark, Faculty of Health Sciences, University of Southern Denmark.
Center for Neuropsychiatric Schizophrenia Research (CNSR) and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Copenhagen University Hospital, Psychiatric Center Glostrup, Denmark.
Autism Res. 2015 Aug;8(4):371-8. doi: 10.1002/aur.1452. Epub 2015 Jan 20.
Autism spectrum disorders (ASD) and schizophrenia are separate disorders, but there is evidence of conversion or comorbid overlap. The objective of this paper was to explore whether deficits in sensory gating, as seen in some schizophrenia patients, can also be found in a group of ASD children compared to neurotypically developed children. An additional aim was to investigate the possibility of subdividing our ASD sample based on these gating deficits. In a case-control design, we assessed gating of the P50 and N100 amplitude in 31 ASD children and 39 healthy matched controls (8-12 years) and screened for differences between groups and within the ASD group. We did not find disturbances in auditory P50 and N100 filtering in the group of ASD children as a whole, nor did we find abnormal P50 and N100 amplitudes. However, the P50 amplitude to the conditioning stimulus was significantly reduced in the Asperger subgroup compared to healthy controls. In contrast to what is usually reported for patients with schizophrenia, we found no evidence for sensory gating deficits in our group of ASD children taken as a whole. However, reduced P50 amplitude to conditioning stimuli was found in the Asperger group, which is similar to what has been described in some studies in schizophrenia patients. There was a positive correlation between the P50 amplitude of the conditioning stimuli and anxiety score in the pervasive developmental disorder not otherwise specified group, which indicates a relation between anxiety and sensory registration in this group.
自闭症谱系障碍（ASD）和精神分裂症是两种不同的疾病，但有证据表明它们之间存在转化或共病重叠。本文的目的是探讨某些精神分裂症患者中出现的感觉门控缺陷，在一组ASD儿童中与发育正常的儿童相比是否也存在。另一个目的是研究根据这些门控缺陷对我们的ASD样本进行细分的可能性。在一项病例对照研究中，我们评估了31名ASD儿童和39名年龄匹配的健康对照儿童（8至12岁）的P50和N100波幅的门控情况，并筛查了组间以及ASD组内的差异。我们在整个ASD儿童组中未发现听觉P50和N100滤波存在干扰，也未发现P50和N100波幅异常。然而，与健康对照相比，阿斯伯格亚组中条件刺激的P50波幅显著降低。与通常报道的精神分裂症患者情况不同，我们在整个ASD儿童组中未发现感觉门控缺陷的证据。然而，在阿斯伯格组中发现条件刺激的P50波幅降低，这与一些精神分裂症患者研究中所描述的情况相似。在未特定的广泛性发育障碍组中，条件刺激的P50波幅与焦虑评分之间存在正相关，这表明该组中焦虑与感觉登记之间存在关联。
