肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞参与哮喘和过敏性疾病的生物标志物。
Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases.
作者信息
Metcalfe Dean D, Pawankar Ruby, Ackerman Steven J, Akin Cem, Clayton Frederic, Falcone Franco H, Gleich Gerald J, Irani Anne-Marie, Johansson Mats W, Klion Amy D, Leiferman Kristin M, Levi-Schaffer Francesca, Nilsson Gunnar, Okayama Yoshimichi, Prussin Calman, Schroeder John T, Schwartz Lawrence B, Simon Hans-Uwe, Walls Andrew F, Triggiani Massimo
机构信息
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 USA.
Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan.
出版信息
World Allergy Organ J. 2016 Feb 11;9:7. doi: 10.1186/s40413-016-0094-3. eCollection 2016.
Abstract
Biomarkers of disease activity have come into wide use in the study of mechanisms of human disease and in clinical medicine to both diagnose and predict disease course; as well as to monitor response to therapeutic intervention. Here we review biomarkers of the involvement of mast cells, basophils, and eosinophils in human allergic inflammation. Included are surface markers of cell activation as well as specific products of these inflammatory cells that implicate specific cell types in the inflammatory process and are of possible value in clinical research as well as within decisions made in the practice of allergy-immunology.
摘要
疾病活动生物标志物已在人类疾病机制研究和临床医学中广泛应用，用于疾病的诊断和病程预测，以及监测治疗干预的反应。本文综述肥大细胞、嗜碱性粒细胞和嗜酸性粒细胞参与人类过敏性炎症的生物标志物。内容包括细胞活化的表面标志物以及这些炎症细胞的特定产物，这些产物表明特定细胞类型参与炎症过程，在临床研究以及过敏免疫实践决策中可能具有价值。
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