Petryna L H
Fiziol Zh (1994). 2002;48(1):67-74.
Effects of an exposure of male vistar rats to 60Co--quanta in the doses of 0.2; 0.5; 1.0; 3.0; 5.0 Gy for 120 days; 7.0 Gy for 20 days and 9.0 Gy for 15 days on the dynamics of the thymic nucleinic acids have been studied. Experiments were conducted in 0.5, 1, 2, 4, 6, 8, 10, 15, 20, 30, 45, 65, 90, 120 days after an exposure to radiation. Essential shifts in metabolism of the nucleinic acids determined on the base of changes in their contents and ratio RNA/DNA have been established. The mass reduction of a radiosensitive organ was mainly due to a decrease in its cellular tissue. The greatest rate of RNA and DNA changes has been found to be on the first day following radiation. Significant reduce in the thymic total DNA synthesis can testify to a sharp decrease in the cellular production by this organ, and the decrease in the RNA synthesis gives evidence for a delay of the differentiation of the thymic cells. Defining the ratio of DNA to RNA can serve a qualitative indicator of the additional generations of the proliferating cells and finally of the size and state of trunk cells.
研究了雄性Vistar大鼠分别接受剂量为0.2、0.5、1.0、3.0、5.0 Gy的60Co射线照射120天，接受剂量为7.0 Gy的照射20天，以及接受剂量为9.0 Gy的照射15天，对胸腺核酸动态变化的影响。实验在辐射暴露后的0.5、1、2、4、6、8、10、15、20、30、45、65、90、120天进行。根据核酸含量及RNA/DNA比值的变化确定了核酸代谢的显著变化。放射敏感器官的质量减轻主要是由于其细胞组织减少。已发现RNA和DNA变化的最大速率出现在辐射后的第一天。胸腺总DNA合成的显著减少可证明该器官细胞生成的急剧减少，而RNA合成的减少则表明胸腺细胞分化延迟。确定DNA与RNA的比值可作为增殖细胞额外增殖以及最终干细胞大小和状态的定性指标。
