Si Qi, Dong Yingbo, Li Yuting, Xu Guoxin, Tang Yilin, Cao Peiyu, Chen Congxin, Ren Fangfang, Li Runda, Sui Yuxiu
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, PR China.
Department of Psychiatry, the Huai'an No.3 People's Hospital, PR China.
Schizophr Res Cogn. 2025 May 24;41:100369. doi: 10.1016/j.scog.2025.100369. eCollection 2025 Sep.
The majority of studies have shown substantially reduced cognitive impairment with ultra-brief pulse (UBP) electroconvulsive therapy (ECT) compared to brief pulse (BP) ECT, though the results remain inconclusive.
This study employed a randomized, double-blind, controlled trial design. A total of 114 patients with schizophrenia (SCZ) were enrolled and received BP ECT (63 participants) or UBP ECT (51 participants). Cognitive function was assessed before and after treatment, with peripheral blood biomarkers and hippocampal magnetic resonance spectroscopy (MRS) data collected concurrently.
No significant baseline differences in demographic or clinical characteristics were observed between the two groups. After the end of ECT sessions, the UBP group and BP group respectively showed advantages in the Trail Making Test (TMT) and Hopkins Verbal Learning Test (HVLT). No between-group differences reached statistical significance in other cognitive tests. The homocysteine, prolactin, inducible nitric oxide synthase and left hippocampal myoinositol (MI) levels were significantly elevated in the UBP group than those in the BP group. Multiple linear regression analysis indicated that right hippocampal MI levels were positively correlated with TMT scores.
There are no significant differences in efficacy between UBP ECT at high-dosage and BP ECT, and further research is required to determine whether this modality can reduce cognitive impairment after treatment.
https://www.chictr.org.cn/showproj.html?proj=243964, registration number: ChiCTR2400091601.
大多数研究表明，与短脉冲电休克疗法（BP-ECT）相比，超短脉冲电休克疗法（UBP-ECT）可显著降低认知障碍，尽管结果仍无定论。
本研究采用随机、双盲、对照试验设计。共纳入114例精神分裂症患者，其中63例接受BP-ECT治疗，51例接受UBP-ECT治疗。在治疗前后评估认知功能，并同时收集外周血生物标志物和海马磁共振波谱（MRS）数据。
两组在人口统计学或临床特征方面未观察到显著的基线差异。ECT疗程结束后，UBP组在连线测验（TMT）中表现出优势，BP组在霍普金斯词语学习测验（HVLT）中表现出优势。在其他认知测试中，两组间差异均未达到统计学意义。UBP组的同型半胱氨酸、催乳素、诱导型一氧化氮合酶和左侧海马肌醇（MI）水平显著高于BP组。多元线性回归分析表明，右侧海马MI水平与TMT分数呈正相关。
高剂量UBP-ECT与BP-ECT在疗效上无显著差异，需要进一步研究以确定这种治疗方式是否能减少治疗后的认知障碍。
https://www.chictr.org.cn/showproj.html?proj=243964，注册号：ChiCTR2400091601。
