Yamazaki Kunio, Boyse Edward A, Bard Judith, Curran Maryanne, Kim David, Ross Susan R, Beauchamp Gary K
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA.
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5612-5. doi: 10.1073/pnas.082093099. Epub 2002 Apr 2.
It has long been recognized that various genetic and metabolic human disorders alter body odor, which is not surprising because they may alter body chemistry. Thus, it has been suggested that some human diseases may be diagnosed by odor alone. In that regard, the mouse mammary tumor virus (MMTV) and its tumors of mice, which may have human counterparts, are of special interest because of the need for basic research possible only in inbred and genetically defined animals. Accordingly, we now show that the mouse MMTV, whether obtained environmentally or genetically transmitted, alters the body odor of mice in both males and females, and regardless of the presence or absence of tumors. These observations, together with the prospect of artificial human odor discrimination, may aid in the search for early human diagnostics.
长期以来，人们已经认识到各种人类遗传和代谢紊乱会改变体味，这并不奇怪，因为它们可能会改变身体的化学成分。因此，有人提出某些人类疾病可能仅通过气味就能诊断出来。在这方面，小鼠乳腺肿瘤病毒（MMTV）及其在小鼠身上引发的肿瘤可能存在人类对应物，由于只有在近交和基因定义明确的动物身上才能进行基础研究，所以它们特别引人关注。相应地，我们现在表明，无论是通过环境方式获得还是通过基因传递的小鼠MMTV，都会改变雄性和雌性小鼠的体味，且无论是否存在肿瘤。这些观察结果，连同人工辨别人类气味的前景，可能有助于寻找早期的人类疾病诊断方法。
