Fujita Y, Chacra A R, Herron A L, Seltzer H S
Diabetes. 1975 Dec;24(12):1072-80. doi: 10.2337/diab.24.12.1072.
The insulin secretory response to a sudden and sustained intravenous glycemic stimulus was measured in three groups of dogs whose antecedent carbohydrate intake ranged from zero to 300 or more grams daily. Insulin outflow rate from the pancreaticoduodenal vein was measured every minute for ten minutes, then at increasing intervals through sixty minutes. It was found that starvation erased the first phase of the biphasic insulin response shown by dogs on ordinary carbohydrate intake and that high-carbohydrate intake abolished the trough between the two phases. The data suggest that, during truly physiologic stimulation of insulin secretion, the latter represents the final stage of a continuum of hormonal synthesis, storage, and release, rather than emanating from one of two separate pools of fast-versus-slow insulin secretion.
在三组犬中测量了对突然且持续的静脉血糖刺激的胰岛素分泌反应，这三组犬先前的碳水化合物摄入量每天从零到300克或更多。在十分钟内每分钟测量一次胰十二指肠静脉的胰岛素流出率，然后在六十分钟内以递增的时间间隔进行测量。结果发现，饥饿消除了普通碳水化合物摄入量的犬所表现出的双相胰岛素反应的第一阶段，而高碳水化合物摄入量消除了两个阶段之间的低谷。数据表明，在真正生理性的胰岛素分泌刺激过程中，胰岛素分泌代表了激素合成、储存和释放连续过程的最后阶段，而不是源自快速与慢速胰岛素分泌的两个独立池之一。
