Plumbridge Jacqueline
Institut de Biologie Physico-chimique, UPR9073, 13 rue Pierre et Marie Curie, 75005, Paris, France.
Curr Opin Microbiol. 2002 Apr;5(2):187-93. doi: 10.1016/s1369-5274(02)00296-5.
Mlc represses several glucose-related genes, including the phosphotransferase system (PTS) genes ptsHI and ptsG. Induction of these genes by glucose occurs as a response to the flux of glucose through the PTS and involves the sequestration of Mlc to membranes containing dephosphorylated PtsG. In addition, ptsG levels are post-transcriptionally regulated by the glycolytic flux. PtsG is, thus, subject to multiple layers of control that, in turn, feed back on the regulation of the PTS by Mlc. The regulatory function of Mlc is compared with that of FruR and of the PTS-regulation-domain-containing protein, BglG.
Mlc抑制多个与葡萄糖相关的基因，包括磷酸转移酶系统（PTS）的ptsHI和ptsG基因。葡萄糖对这些基因的诱导是对葡萄糖通过PTS的通量的一种反应，并且涉及Mlc与含有去磷酸化PtsG的膜的隔离。此外，ptsG水平受到糖酵解通量的转录后调控。因此，PtsG受到多层控制，这些控制又会反馈到Mlc对PTS的调控上。将Mlc的调节功能与FruR以及含有PTS调节结构域的蛋白质BglG的调节功能进行了比较。
