Voskuhl Rhonda R
UCLA Department of Neurology, Reed Neurological Research Center, Room A-145, 710 Westwood Plaza, Los Angeles, CA 90024, USA.
Curr Neurol Neurosci Rep. 2002 May;2(3):277-86. doi: 10.1007/s11910-002-0087-1.
Gender-related issues in multiple sclerosis include the important and widely accepted clinical observations that men are less susceptible to the disease than women and also that disease activity in multiple sclerosis is decreased during late pregnancy. This article reviews mechanisms underlying each of these clinical observations and discusses the role of sex hormones in each. Specifically, the protective role of testosterone in young men and the protective role of the pregnancy hormone estriol in pregnant women are discussed. Rationale for novel therapies in multiple sclerosis based on the protective roles of these sex hormones is presented.
男性比女性更不易患该病，而且在妊娠晚期多发性硬化症的疾病活动会减弱。本文回顾了这些临床观察结果背后的机制，并讨论了性激素在其中各自所起的作用。具体而言，探讨了睾酮在年轻男性中的保护作用以及妊娠激素雌三醇在孕妇中的保护作用。还介绍了基于这些性激素保护作用的多发性硬化症新疗法的理论依据。
