Qi Jianhua, Ojika Makoto, Sakagami Youji
Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, 464-8601, Nagoya, Japan.
Bioorg Med Chem. 2002 Jun;10(6):1961-6. doi: 10.1016/s0968-0896(02)00006-8.
Two new steroid glycosides, named linckosides A and B, were isolated from the Okinawan starfish Linckia laevigata, and their stereostructures were elucidated by spectroscopic methods and chemical derivatization. Each of them possesses two monosaccharide units at C-3 and C-29 of a polyhydroxylated steroid aglycon. These steroid glycosides showed not only notable neuritogenic activity against PC12 cells but also significant synergistic effects on the NGF-induced neuronal differentiation of PC12 cells. Linckoside B showed higher activities than those of linckoside A, though the structural difference is only the kind of a sugar.
从冲绳海星光滑指海星（Linckia laevigata）中分离出两种新的甾体糖苷，命名为林可糖苷A和B，并通过光谱方法和化学衍生化确定了它们的立体结构。它们各自在多羟基甾体苷元的C-3和C-29位具有两个单糖单元。这些甾体糖苷不仅对PC12细胞显示出显著的促神经突生长活性，而且对神经生长因子（NGF）诱导的PC12细胞神经元分化具有显著的协同作用。尽管结构差异仅在于糖的种类，但林可糖苷B的活性高于林可糖苷A。
