Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, China.
First Motorized Detachment of Shanghai Armed Police Corps, Shanghai 200126, China.
Mar Drugs. 2018 Mar 13;16(3):92. doi: 10.3390/md16030092.
Four new polyhydroxysteroidal glycosides-culcinosides A-D (, , , and )-along with three known compounds-echinasteroside C (), linckoside F (), and linckoside L3 ()-were isolated from the ethanol extract of starfish collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated.
从南海西沙群岛采集的海星乙醇提取物中分离得到了四种新的多羟基甾体糖苷——culcinosides A-D（、、、和），以及三种已知化合物——echinasteroside C（）、linckoside F（）和 linckoside L3（）。通过广泛的光谱研究和化学证据，特别是二维（2D）NMR 技术，阐明了新化合物的结构。评估了新化合物对人神经胶质瘤细胞系 U87、U251 和 SHG44 的细胞毒性。
