Stoll Guido, Jander Sebastian, Myers Robert R
Department of Neurology, Julius-Maximilians-Universität, Würzburg, Germany.
J Peripher Nerv Syst. 2002 Mar;7(1):13-27. doi: 10.1046/j.1529-8027.2002.02002.x.
This review article on the degeneration and regeneration of peripheral nerve fibers was presented as a Plenary Lecture at the 2001 meeting of the Peripheral Nerve Society. It is accompanied by a reprint of Augustus Waller's 1850 article, which gave rise to the pathologic process termed Wallerian degeneration. This review is focused on the role of neuroinflammation in Wallerian degeneration and how immune mediators contribute to both axonal degeneration and regeneration. Similarities and differences between the PNS and CNS in terms of inflammation and microglial activation after nerve injury are discussed, and point towards progress in understanding the failure of nerve fiber regeneration in the CNS.
这篇关于周围神经纤维退变与再生的综述文章是作为全会演讲在2001年周围神经学会会议上发表的。文章还附带了奥古斯塔斯·沃勒1850年文章的重印版，正是这篇文章引发了被称为沃勒氏变性的病理过程。本综述聚焦于神经炎症在沃勒氏变性中的作用，以及免疫介质如何对轴突退变和再生产生影响。文中讨论了周围神经系统（PNS）和中枢神经系统（CNS）在神经损伤后炎症和小胶质细胞激活方面的异同，这些异同指向了在理解中枢神经系统神经纤维再生失败方面取得的进展。
