Villalonga A., Bernardo M., Gomar C., Fita G., Escobar R., Pacheco M.
Departments of Anesthesiology and Psychiatry, Hospital Clinic i Provincial, Medical School, University of Barcelona, Barcelona, Spain.
Convuls Ther. 1993;9(2):108-111.
Propofol provokes a slight hypotensive effect that could mitigate the cardiovascular response to electroconvulsive therapy (ECT). In this study we compared the effects of propofol and thiopental for ECT anesthesia in seven women (22-67 years of age). Anesthesia was induced with either thiopental or propofol, and with atropine and suxamethonium for each treatment. The first anesthesia was assigned to thiopental or propofol at random; the next anesthesia was induced with the other drug, and alternated thereafter. Systolic blood pressure, diastolic blood pressure (DBP), and heart rate (HR) were recorded before anesthesia, after anesthetic induction, and 1 and 5 min after ECT. ECT-induced increases in DBP and HR were less marked with propofol than with thiopental. Seizure durations were decreased with propofol compared with thiopental.
丙泊酚会引发轻微的降压作用，这可能会减轻电休克治疗（ECT）时的心血管反应。在本研究中，我们比较了丙泊酚和硫喷妥钠用于7名女性（22至67岁）ECT麻醉的效果。每种治疗均使用硫喷妥钠或丙泊酚诱导麻醉，并联合使用阿托品和琥珀胆碱。首次麻醉随机分配使用硫喷妥钠或丙泊酚；下次麻醉则使用另一种药物诱导，并交替进行。在麻醉前、麻醉诱导后以及ECT后1分钟和5分钟记录收缩压、舒张压（DBP）和心率（HR）。与硫喷妥钠相比，丙泊酚使ECT诱导的DBP和HR升高不那么明显。与硫喷妥钠相比，丙泊酚使癫痫发作持续时间缩短。
