Nishiwaki Hirokazu, Shahidi Mahnaz, Vitale Susan, Alexander Judith, Asran Sanjay, Mori Marek, Blair Norman P, Zeimer Ran
Wilmer Ophthalmological Institute, Johns Hopkins University, Baltimore, Maryland, USA.
Ophthalmic Surg Lasers. 2002 Mar-Apr;33(2):127-34.
To determine the association of retinal thickening (RT) with clinically observable retinal pathologies in eyes with mild nonproliferative diabetic retinopathy.
Using an objective quantitative imaging method (Retinal Thickness Analyzer), the ratio relative to normal RT (RTI) was measured in 23 eyes with and 35 eyes without clinically observable diabetic fundus pathology. RTI was analyzed in relation to presence of mild diabetic retinal lesions in the +/-0.5 mm vicinity.
The percent of eyes with RTI significantly above normal values did not differ significantly between eyes with and without retinopathy (30% vs 34%). Mean RTI was not associated with local presence of microaneurysms (P=0.92), soft exudates (P=0.55), or retinal hemorrhages (P=0.31). Areas without hard exudates had significantly greater mean RTI (1.10) than areas with exudates (0.97, P=0.009).
In diabetic patients with mild retinopathy, areas with and without clinically observable retinal pathologies had similar retinal thickness. We conclude that clinical strategies for detection of retinal thickening should not be limited to areas with visible fundus pathologies.
确定轻度非增殖性糖尿病视网膜病变患者视网膜增厚（RT）与临床可观察到的视网膜病变之间的关联。
采用客观定量成像方法（视网膜厚度分析仪），对23例有临床可观察到的糖尿病眼底病变的患眼和35例无此病变的患眼测量相对于正常视网膜厚度（RT）的比值（RTI）。分析RTI与±0.5 mm范围内轻度糖尿病视网膜病变的存在情况之间的关系。
视网膜病变组和无视网膜病变组中RTI显著高于正常值的患眼百分比无显著差异（30%对34%）。平均RTI与微动脉瘤的局部存在（P = 0.92）、软性渗出物（P = 0.55）或视网膜出血（P = 0.31）无关。无硬性渗出物的区域平均RTI（1.10）显著高于有渗出物的区域（0.97，P = 0.009）。
在轻度视网膜病变的糖尿病患者中，有和无临床可观察到的视网膜病变的区域视网膜厚度相似。我们得出结论，检测视网膜增厚的临床策略不应局限于眼底有可见病变的区域。
