Blair Norman P, Shahidi Mahnaz, Lai Wico W, Zelkha Ruth
Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois 60612, USA.
Retina. 2008 Oct;28(8):1097-103. doi: 10.1097/IAE.0b013e318177f8ec.
Microaneurysms commonly are believed to be related causally to retinal thickening in diabetic retinopathy, especially by leaking. The hypothesis that thicker areas of retina in diabetic retinopathy have more microaneurysms per unit area than areas that are not as thick was tested.
Retinal thickness analysis was performed with a prototype instrument for 27 eyes of 27 diabetic patients and 22 normal eyes of 22 healthy subjects. Maps of retinal thickness were created, and microaneurysms were counted in zones having four levels of retinal thickness.
There was no increase in either total microaneurysms or apparent leaking microaneurysms per unit area with increasing levels of retinal thickness (P = 0.77 and 0.87, respectively).
Some microaneurysms may not cause thickening, or other factors may contribute to retinal thickening in diabetic retinopathy. The results may have implications on the pathogenesis of diabetic macular edema.
人们普遍认为微动脉瘤与糖尿病性视网膜病变中的视网膜增厚存在因果关系，尤其是通过渗漏导致。本研究对糖尿病性视网膜病变中较厚区域每单位面积的微动脉瘤是否比不太厚的区域更多这一假设进行了检验。
使用一台原型仪器对27例糖尿病患者的27只眼和22名健康受试者的22只正常眼进行视网膜厚度分析。创建视网膜厚度图，并在具有四个视网膜厚度水平的区域中对微动脉瘤进行计数。
随着视网膜厚度水平的增加，单位面积的微动脉瘤总数或明显渗漏的微动脉瘤数量均未增加（P值分别为0.77和0.87）。
一些微动脉瘤可能不会导致增厚，或者其他因素可能导致糖尿病性视网膜病变中的视网膜增厚。这些结果可能对糖尿病性黄斑水肿的发病机制有影响。
