Ship Jonathan A, Pillemer Stanley R, Baum Bruce J
Department of Oral Medicine, Bluestone Center for Clinical Research, New York University College of Dentistry, 345 East 24th Street, New York, NY 10010, USA.
J Am Geriatr Soc. 2002 Mar;50(3):535-43. doi: 10.1046/j.1532-5415.2002.50123.x.
Saliva is essential for the preservation of oral-pharyngeal health, and disorders of salivary physiology are associated with numerous oral and pharyngeal problems, particularly in older people. Although salivary function is remarkably intact in healthy aging, medical problems, medications, and head and neck radiotherapy can cause salivary dysfunction and complaints of xerostomia among older people. Sjögren's syndrome, an autoimmune exocrinopathy, is the most common medical disease associated with salivary dysfunction. Medications with anticholinergic side effects will impair salivary output, and head and neck radiotherapy for cancer will cause permanent destruction of salivary glands. Treatments for salivary problems are based upon establishing a diagnosis, protecting oral and pharyngeal health, stimulating remaining glands, and replacing lost salivary fluids.
唾液对于维持口咽健康至关重要,唾液生理紊乱与众多口腔和咽部问题相关,尤其是在老年人中。尽管在健康老龄化过程中唾液功能相当完好,但医学问题、药物以及头颈部放疗会导致老年人唾液功能障碍和口干症状。干燥综合征是一种自身免疫性外分泌病,是与唾液功能障碍相关的最常见医学疾病。具有抗胆碱能副作用的药物会损害唾液分泌,而针对癌症的头颈部放疗会导致唾液腺永久性破坏。唾液问题的治疗基于明确诊断、保护口咽健康、刺激剩余腺体以及补充流失的唾液。