Deininger Martin H, Meyermann Richard, Schluesener Hermann J
Institute of Brain Research, University of Tübingen, Calwer Str. 3, D-72076 Tübingen, Germany.
FEBS Lett. 2002 Mar 13;514(2-3):115-21. doi: 10.1016/s0014-5793(02)02430-4.
The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma-inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins are probably identical with AIF-1 termed Iba1 (ionized Ca(2+)-binding adapter), MRF-1 (microglia response factor) and daintain. Considerable but not complete sequence identity with AIF-1 has been described for IRT-1 (interferon-responsive transcript), BART-1 (balloon angioplasty-responsive transcript), and other, yet unassigned alternatively spliced variants. In this review, genomic and functional characteristics of AIF-1-related proteins are summarized and a common nomenclature is proposed.
同种异体移植炎症因子-1（AIF-1）是一种17 kDa的γ干扰素诱导的Ca(2+)结合EF手蛋白，其编码于HLA III类基因组区域内。三种蛋白可能与AIF-1相同，分别称为Iba1（离子化Ca(2+)结合衔接蛋白）、MRF-1（小胶质细胞反应因子）和daintain。已报道IRT-1（干扰素反应性转录本）、BART-1（球囊血管成形术反应性转录本）以及其他尚未分类的可变剪接变体与AIF-1具有相当但不完全的序列同一性。在本综述中，总结了AIF-1相关蛋白的基因组和功能特征，并提出了通用命名法。
