Bonilla Myriam, Cunningham Kyle W
Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA.
Sci STKE. 2002 Apr 9;2002(127):pe17. doi: 10.1126/stke.2002.127.pe17.
Calcium is one of the most ubiquitous second messengers, in addition to being a fundamentally important cofactor for many proteins' functions. Thus, cells from fungi to plants to animals have evolved mechanisms for carefully controlling calcium concentrations in their organelles and cytosol. This perspective discusses the similarities and differences between yeast and animals in cation channels of two families: the transient receptor potential channels (TRPCs) and voltage-gated calcium channels (VGCCs). One of the key differences highlighted is in the channels implicated in the response of yeast and animal cells to depletion of calcium from intracellular stores, and the differences in localization of these channels between yeast and animal cells. Understanding the logic of fungal Ca(2+) channels, therefore, may provide new insights into the organization and regulation of cellular calcium signaling networks in animals.
钙是最普遍存在的第二信使之一，同时也是许多蛋白质功能的重要辅助因子。因此，从真菌到植物再到动物，细胞都进化出了精确控制细胞器和细胞质中钙浓度的机制。本文探讨了酵母和动物在两个家族阳离子通道中的异同：瞬时受体电位通道（TRPC）和电压门控钙通道（VGCC）。突出的关键差异之一在于，酵母和动物细胞对细胞内钙库中钙耗竭的反应所涉及的通道，以及这些通道在酵母和动物细胞中的定位差异。因此，了解真菌钙通道的逻辑，可能为深入了解动物细胞钙信号网络的组织和调控提供新的见解。
