Experimentelle und Klinische Pharmakologie und Toxikologie, Medizinische Fakultät, Universität des Saarlandes, 66421 Homburg, Germany.
FEBS Lett. 2010 May 17;584(10):2028-32. doi: 10.1016/j.febslet.2009.12.035. Epub 2009 Dec 24.
Transient receptor potential (TRP) channels are found among mammals, flies, worms, ciliates, Chlamydomonas, and yeast but are absent in plants. These channels are believed to be tetramers of proteins containing six transmembrane domains (TMs). Their primary structures are diverse with sequence similarities only in some short amino acid sequence motifs mainly within sequences covering TM5, TM6, and adjacent domains. In the yeast genome, there is one gene encoding a TRP-like sequence. This protein forms an ion channel in the vacuolar membrane and is therefore called Yvc1 for yeast vacuolar conductance 1. In the following we summarize its prominent features.
瞬时受体电位 (TRP) 通道存在于哺乳动物、苍蝇、蠕虫、纤毛虫、衣藻和酵母中，但在植物中不存在。这些通道被认为是包含六个跨膜域 (TM) 的蛋白质的四聚体。它们的一级结构是多样的，只有在一些短的氨基酸序列基序中具有序列相似性，这些基序主要存在于覆盖 TM5、TM6 和相邻结构域的序列中。在酵母基因组中，有一个基因编码一个类似 TRP 的序列。这种蛋白质在液泡膜中形成一个离子通道，因此被称为 Yvc1，即酵母液泡电导 1。在下面我们总结其主要特征。
