迁移细胞中黏附的组装、拆卸和周转——一次又一次，反复进行。

Adhesion assembly, disassembly and turnover in migrating cells -- over and over and over again.

作者信息

Webb Donna J, Parsons J Thomas, Horwitz Alan F

机构信息

Department of Cell Biology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.

出版信息

Nat Cell Biol. 2002 Apr;4(4):E97-100. doi: 10.1038/ncb0402-e97.

DOI:10.1038/ncb0402-e97

PMID:11944043

Abstract

Cell migration is an integrated process that requires the continuous, coordinated formation and disassembly of adhesions. These processes are complex and require a regulated interaction of numerous molecules, and the activation of specific signalling pathways. Even though understanding these processes is challenging, important insights are beginning to emerge, and the technology to facilitate significant advances in this area is now in place.

摘要

细胞迁移是一个综合过程，需要黏附的持续、协调形成和分解。这些过程很复杂，需要众多分子的调控相互作用以及特定信号通路的激活。尽管理解这些过程具有挑战性，但重要的见解已开始显现，且推动该领域取得重大进展的技术现已具备。