Williams Benjamin B, al Hallaq Hania, Chandramouli G V R, Barth Eugene D, Rivers Jonathan N, Lewis Marta, Galtsev Valeri E, Karczmar Gregory S, Halpern Howard J
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, Illinois, USA.
Magn Reson Med. 2002 Apr;47(4):634-8. doi: 10.1002/mrm.10089.
Electron paramagnetic resonance imaging (EPRI) promises to provide new insights into the physiology of tissues in health and disease. Understanding the in vivo imaging capability of this new modality requires comparison with other physiologically responsive techniques. Here, an initial comparison between 2D EPR spatial imaging of a narrow single line injectable paramagnetic trityl spin probe and 2D slice-selected carbogen subtraction BOLD MRI is presented. The images were obtained from the same FSa fibrosarcoma grown in the leg of a C3H mouse. This tumor was unusual in comparison with others imaged with subtraction BOLD MRI because of its peripheral distribution of intensity. The spatial distribution of the EPR spin probe showed the same peripheral distribution. The pixel resolutions of these images are comparable. These images provide an early in vivo comparison of EPRI with a well-established imaging modality. The comparison validates the in vivo distribution of spin probe as imaged with EPRI, and provides a proof of principle for the comparison of BOLD and EPRI.
电子顺磁共振成像（EPRI）有望为健康和疾病状态下的组织生理学提供新的见解。要了解这种新成像方式的体内成像能力，需要与其他生理响应技术进行比较。在此，展示了窄单线可注射顺磁性三苯甲基自旋探针的二维EPR空间成像与二维切片选择的二氧化碳减除血氧水平依赖性功能磁共振成像（BOLD MRI）之间的初步比较。图像取自生长于C3H小鼠腿部的同一FSa纤维肉瘤。与其他用减除BOLD MRI成像的肿瘤相比，该肿瘤因其强度的外周分布而显得不同寻常。EPR自旋探针的空间分布显示出相同的外周分布。这些图像的像素分辨率相当。这些图像提供了EPRI与一种成熟成像方式的早期体内比较。该比较验证了用EPRI成像的自旋探针的体内分布，并为BOLD和EPRI的比较提供了原理证明。
