Department of Radiology, University of Chicago, IL, USA.
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA.
J Physiol. 2021 Mar;599(6):1759-1767. doi: 10.1113/JP278816. Epub 2020 Jun 28.
Measuring molecular oxygen levels in vivo has been the cornerstone of understanding the effects of hypoxia in normal tissues and malignant tumors. Here we discuss the advances in a variety of partial pressure of oxygen ( ) measurements and imaging techniques and relevant oxygen thresholds. A focus on electron paramagnetic resonance (EPR) imaging shows the validation of treating hypoxic tumours with a threshold of ≤ 10 Torr, and demonstrates utility for in vivo oxygen imaging, as well as its current and future role in cancer studies.
测量体内的分子氧水平一直是了解缺氧对正常组织和恶性肿瘤影响的基石。在这里，我们讨论了各种氧分压（ ）测量和成像技术以及相关氧阈值的进展。重点介绍电子顺磁共振（EPR）成像，展示了用 ≤ 10 托的阈值治疗缺氧肿瘤的有效性，并证明了其在体内氧成像中的应用价值，以及其在癌症研究中的当前和未来作用。
