Epel Boris, Kotecha Mrignayani, Halpern Howard J
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, United States; Center for EPR Imaging In Vivo Physiology, University of Chicago, Chicago, IL 60637, United States.
Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago IL 60607, United States.
J Magn Reson. 2017 Jul;280:149-157. doi: 10.1016/j.jmr.2017.04.017. Epub 2017 Apr 30.
The value of any measurement and a fortiori any measurement technology is defined by the reproducibility and the accuracy of the measurements. This implies a relative freedom of the measurement from factors confounding its accuracy. In the past, one of the reasons for the loss of focus on the importance of imaging oxygen in vivo was the difficulty in obtaining reproducible oxygen or pO images free from confounding variation. This review will briefly consider principles of electron paramagnetic oxygen imaging and describe how it achieves absolute oxygen measurements. We will provide a summary review of the progress in biomedical EPR imaging, predominantly in cancer biology research, discuss EPR oxygen imaging for cancer treatment and tissue graft assessment for regenerative medicine applications.
任何测量的价值，更不用说任何测量技术的价值，都是由测量的可重复性和准确性来定义的。这意味着测量相对不受混淆其准确性的因素影响。过去，人们不再关注体内氧成像重要性的原因之一是难以获得可重复的、不受混淆变化影响的氧或pO图像。本综述将简要探讨电子顺磁共振氧成像的原理，并描述其如何实现绝对氧测量。我们将对生物医学电子顺磁共振成像的进展进行总结性综述，主要是在癌症生物学研究方面，讨论用于癌症治疗的电子顺磁共振氧成像以及用于再生医学应用的组织移植评估。
