Dzik-Jurasz A S K, Murphy P S, George M, Prock T, Collins D J, Swift I, Leach M O, Rowland I J
CRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research and the Royal Marsden NHS Trust, Surrey, UK.
Magn Reson Med. 2002 Apr;47(4):809-11. doi: 10.1002/mrm.10108.
This study was designed to determine whether 1H-MR spectra of locally advanced human rectal adenocarcinoma could be acquired in vivo at 1.5 T. Despite the relatively large size of these neoplasms, only six out of 21 tumors accommodated a voxel size of 8 cm3. This was due to air pockets within the tumor mass, which limited voxel positioning. Localized proton spectra were acquired at short (20 ms) and long (135 ms) echo times (TEs) using a single-voxel technique. The most commonly detected metabolites were choline and lipid.
本研究旨在确定能否在1.5 T磁场下在体获取局部进展期人类直肠腺癌的1H磁共振波谱。尽管这些肿瘤体积相对较大，但21个肿瘤中只有6个能容纳8 cm3的体素大小。这是由于肿瘤块内存在气腔，限制了体素定位。使用单体素技术在短（20 ms）和长（135 ms）回波时间（TE）下获取局部质子波谱。最常检测到的代谢物是胆碱和脂质。
