Barrionuevo M, Alferez M J M, Lopez Aliaga I, Sanz Sampelayo M R, Campos M S
Department of Physiology, Faculty of Pharmacy, University of Granada, Spain.
J Dairy Sci. 2002 Mar;85(3):657-64. doi: 10.3168/jds.s0022-0302(02)74120-9.
The search for diets that improve the digestive and metabolic use of iron and copper in malabsorption syndrome led us to study goat milk for particular nutritional characteristics and compare it with cow milk, which is usually supplied. We studied the metabolism of iron and copper in transected rats (control) and in resected rats (resection of 50% of the distal small intestine). The diets used were the standard diet recommended by the American Institute of Nutrition and diets based on goat or cow milk. Intestinal resection reduced the apparent digestibility coefficient (ADC) of iron in the three diets tested. In the transected and resected rats, the ADC of iron was highest with the goat milk diet, followed by the standard diet and lowest with the cow milk diet. The ADC of copper was not affected by intestinal resection in the animals fed the goat milk diet, and was higher than that in the two groups of animals fed the other diets. Intestinal resection reduced the ADC of copper with the standard diet and the cow milk diet. When both groups of animals were fed the goat milk diet, the deposit of iron in the organs was greater than with those fed the cow milk diet and similar to that in those animals given the standard diet. The copper content in the kidneys was lower in the resected than in the transected animals, except in the case of those fed the goat milk diet, in which it was similar to that of the control (transected) rats. This study shows the beneficial effect of goat milk, with respect to cow milk, on the metabolism of iron and copper in control rats, especially those with malabsorption syndrome.
寻找能改善吸收不良综合征中铁和铜的消化及代谢利用的饮食，促使我们研究山羊奶独特的营养特性，并将其与通常供应的牛奶进行比较。我们研究了横断大鼠（对照组）和切除大鼠（切除远端小肠的50%）中铁和铜的代谢。所用饮食为美国营养学会推荐的标准饮食以及以山羊奶或牛奶为基础的饮食。肠道切除降低了所测试的三种饮食中铁的表观消化率系数（ADC）。在横断和切除的大鼠中，山羊奶饮食组中铁的ADC最高，其次是标准饮食组，牛奶饮食组最低。在喂食山羊奶饮食的动物中，肠道切除对铜的ADC没有影响，且高于喂食其他两种饮食的两组动物。肠道切除降低了标准饮食组和牛奶饮食组中铜的ADC。当两组动物都喂食山羊奶饮食时，器官中铁的沉积量大于喂食牛奶饮食的动物，且与喂食标准饮食的动物相似。除了喂食山羊奶饮食的动物外，切除大鼠肾脏中的铜含量低于横断大鼠，而喂食山羊奶饮食的动物其肾脏铜含量与对照（横断）大鼠相似。这项研究表明，相对于牛奶，山羊奶对对照大鼠尤其是患有吸收不良综合征的大鼠的铁和铜代谢具有有益作用。
