Karran S J, Leach K G, Wisbey M L, Blumgart L H
J Nucl Med. 1975 May;16(5):377-9.
Intramesenteric and intrasplenic injections of 99mTc-sulfur colloid in the rat resulted in significant differences between the mean uptakes in only some of the liver lobes. More important were the wider interlobular variations seen in the intrasplenic and intramesenteric routes of injection compared with the intravenous route. It is suggested that these differences result from laminar blood flow in the portal vein. In the light of our findings, previous evidence must be considered inconclusive. Laminar flow appears to vary between individual animals and may also vary from time to time in the same animal. Caution is therefore advised when other than systemic routes of injection are used.
在大鼠体内进行肠系膜内和脾内注射99mTc-硫胶体后，仅部分肝叶的平均摄取量之间存在显著差异。更重要的是，与静脉注射途径相比，在脾内和肠系膜内注射途径中观察到的小叶间差异更大。提示这些差异是由门静脉的层流引起的。根据我们的研究结果，以前的证据必须被认为是不确定的。层流在个体动物之间似乎有所不同，并且在同一动物体内也可能随时间变化。因此，当使用非全身注射途径时建议谨慎。
