Cabrejas M, Ladizesky M, Mautalen C A
J Nutr. 1975 Dec;105(12):1562-6. doi: 10.1093/jn/105.12.1562.
The chronic ingestion of the leaves of the plant Solanum malacoxylon (SM) causes an endemic disease in the cattle of some areas of Buenos Aires province. The animals affected manifest loss of appetite and weight, hypercalcemia, hyperphosphatemia, and ectopic calcifications. In order to study the mechanism of the hypercalcemia provoked by the administration of SM, a calcium kinetic study was performed in control and treated adult intact rats. The animals receiving SM showed higher levels of serum calcium throughout the study. The body excretion of 47Ca and the size of the most rapidly exchangeable calcium pool were also elevated. On the other hand, the bone accretion rate and the urinary excretion of total hydroxyproline were significantly diminished. The results indicate that during the early phase of SM administration in intact rats, bone turnover rate is depressed.
长期摄入茄属植物马勒考西龙（Solanum malacoxylon，SM）的叶子会在布宜诺斯艾利斯省某些地区的牛群中引发一种地方病。受影响的动物表现出食欲不振、体重减轻、高钙血症、高磷血症和异位钙化。为了研究给予SM引起高钙血症的机制，在对照和经处理的成年未阉割大鼠中进行了钙动力学研究。在整个研究过程中，接受SM的动物血清钙水平较高。47Ca的身体排泄量和交换最快的钙池大小也有所升高。另一方面，骨生长率和总羟脯氨酸的尿排泄量显著降低。结果表明，在未阉割大鼠给予SM的早期阶段，骨转换率降低。
