Blanusa M, Bogunović M, Matković V
Pflugers Arch. 1978 Aug;375(3):233-8. doi: 10.1007/BF00582435.
The aim of this study was to establish the influence of age and sex on the kinetic and morphometric parameters of calcium metabolism. Normal values of kinetic parameters were determined in normal adult rats of different ages (4--20 months) and both sexes. Urinary hydrophyline excretion was also assessed and morphometric measurements of the femur were performed. Kinetic parameters expressed as rate constants showed a lowering of calcium turnover (kr) in the rapidly exchangeable calcium compartment until the age of 12 months and urinary and fecal rate constants (ku and kf) showed a small increase. Males exhibited a lower calcium turnover (kT) as well as lower urinary and fecal rate constants. Hydroxyproline excretion diminished with age in both sexes. Lower values were recorded in males. Morphometric parameters of femurs showed no bone loss within the examined age. The results show that differences between the sexes exist in the sense of a faster calcium turnover, higher calcium excretion rate constants, higher collagen degradation and higher bone density in adult female rats.
本研究的目的是确定年龄和性别对钙代谢动力学及形态学参数的影响。测定了不同年龄（4 - 20个月）和性别的正常成年大鼠的动力学参数正常值。还评估了尿中羟脯氨酸排泄情况，并对股骨进行了形态学测量。以速率常数表示的动力学参数显示，直到12个月龄时，快速可交换钙池中的钙周转率（kr）降低，而尿和粪便速率常数（ku和kf）略有增加。雄性大鼠的钙周转率（kT）以及尿和粪便速率常数较低。两性的羟脯氨酸排泄均随年龄减少。雄性记录到的值更低。在所检查的年龄范围内，股骨的形态学参数未显示骨质流失。结果表明，成年雌性大鼠在钙周转率更快、钙排泄速率常数更高、胶原蛋白降解更高和骨密度更高的意义上存在性别差异。
