Lin Weiying, Lawrence David S
Department of Biochemistry, The Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
J Org Chem. 2002 Apr 19;67(8):2723-6. doi: 10.1021/jo0163851.
Caged analogues of biologically active compounds have received widespread attention as temporally and spatially controlled probes of cell-based processes. Recently, a coumarin-4-ylmethyl derivative has been used to cage carboxylates, sulfonates, carbamates, and phosphates. We describe herein a synthetic strategy that furnishes photosensitive caged diols and provides an entry into the protection/photodeprotection of functionality with modest leaving group abilities.
生物活性化合物的笼形类似物作为基于细胞过程的时空可控探针受到了广泛关注。最近，一种香豆素-4-基甲基衍生物已被用于笼蔽羧酸盐、磺酸盐、氨基甲酸盐和磷酸盐。我们在此描述了一种合成策略，该策略可提供光敏笼形二醇，并为具有适度离去基团能力的官能团的保护/光脱保护提供了一条途径。
