Watts D A, Satsangi J
Gastrointestinal Unit, The University of Edinburgh, Western General Hospital, Edinburgh, UK.
Gut. 2002 May;50 Suppl 3(Suppl 3):III31-6. doi: 10.1136/gut.50.suppl_3.iii31.
Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence that both genetic and environmental factors are important in disease pathogenesis, and gene-environmental interaction determines disease susceptibility and behaviour.
在经历了一段相对停滞的漫长时期后，过去几年里在理解慢性炎症性肠病（克罗恩病和溃疡性结肠炎）的发病机制方面取得了实际进展。临床经验、流行病学研究和分子遗传学已提供有力证据，表明遗传因素和环境因素在疾病发病机制中都很重要，且基因-环境相互作用决定疾病易感性和表现。
