Department of Dermatology Daniele Innocenzi, A. Fiorini Hospital, Sapienza University of Rome, Terracina, Italy.
Biomed Res Int. 2013;2013:983902. doi: 10.1155/2013/983902. Epub 2013 Jul 21.
For a long time the relationship between inflammatory bowel diseases (IBDs) and psoriasis has been investigated by epidemiological studies. It is only starting from the 1990s that genetic and immunological aspects have been focused on. Psoriasis and IBD are strictly related inflammatory diseases. Skin and bowel represent, at the same time, barrier and connection between the inner and the outer sides of the body. The most important genetic correlations involve the chromosomal loci 6p22, 16q, 1p31, and 5q33 which map several genes involved in innate and adaptive immunity. The genetic background represents the substrate to the common immune processes involved in psoriasis and IBD. In the past, psoriasis and IBD were considered Th1-related disorders. Nowadays the role of new T cells populations has been highlighted. A key role is played by Th17 and T-regs cells as by the balance between these two cells types. New cytokines and T cells populations, as IL-17A, IL-22, and Th22 cells, could play an important pathogenetic role in psoriasis and IBD. The therapeutic overlaps further support the hypothesis of a common pathogenesis.
长期以来，炎症性肠病（IBD）和银屑病之间的关系一直受到流行病学研究的关注。直到 20 世纪 90 年代，人们才开始关注遗传和免疫方面的问题。银屑病和 IBD 是两种密切相关的炎症性疾病。皮肤和肠道既是身体内部和外部之间的屏障，也是连接两者的纽带。最重要的遗传相关性涉及染色体位置 6p22、16q、1p31 和 5q33，这些位置映射了几个参与固有和适应性免疫的基因。遗传背景是银屑病和 IBD 共同免疫过程的基础。过去，银屑病和 IBD 被认为与 Th1 相关的疾病。如今，新的 T 细胞群体的作用已被强调。Th17 和 T-regs 细胞以及这两种细胞类型之间的平衡起着关键作用。新的细胞因子和 T 细胞群体，如 IL-17A、IL-22 和 Th22 细胞，可能在银屑病和 IBD 的发病机制中发挥重要作用。治疗上的重叠进一步支持了共同发病机制的假说。
