Svensson Liselott A, Henning Petra, Lagergård Teresa
Department of Medical Microbiology and Immunology, Göteborg University, S-4136 Göteborg, Sweden.
Infect Immun. 2002 May;70(5):2665-9. doi: 10.1128/IAI.70.5.2665-2669.2002.
Haemophilus ducreyi, the etiologic agent of the sexually transmitted disease chancroid, produces a cytolethal distending toxin (HdCDT) that inhibits mammalian cell proliferation. We investigated the effects of HdCDT on normal human endothelial cells and on tubule formation in an in vitro model of angiogenesis. Endothelial cells were arrested in the G2 phase of the cell cycle, and tubule formation was inhibited in a dose-dependent manner. The antiproliferative activities of HdCDT on endothelial cells might contribute to the characteristic slow healing and persistence of chancroid ulcers.
杜克雷嗜血杆菌是性传播疾病软下疳的病原体，它产生一种细胞致死性膨胀毒素（HdCDT），可抑制哺乳动物细胞增殖。我们在体外血管生成模型中研究了HdCDT对正常人内皮细胞和小管形成的影响。内皮细胞停滞在细胞周期的G2期，并且小管形成受到剂量依赖性抑制。HdCDT对内皮细胞的抗增殖活性可能导致软下疳溃疡典型的愈合缓慢和持续存在。
