假结核耶尔森菌产生一种细胞毒性坏死因子。
Yersinia pseudotuberculosis produces a cytotoxic necrotizing factor.
作者信息
Lockman Hank A, Gillespie Rebecca A, Baker Beth D, Shakhnovich Elizabeth
机构信息
Children's Research Institute, Children's Hospital, Columbus, Ohio 43205-2696, USA.
出版信息
Infect Immun. 2002 May;70(5):2708-14. doi: 10.1128/IAI.70.5.2708-2714.2002.
Abstract
Cell extracts from Yersinia pseudotuberculosis induced multinucleation in HEp-2 cells in a manner similar to the effect caused by Escherichia coli cytotoxic necrotizing factor (CNF). The activity was not dependent on the Yersinia 70-kb virulence plasmid, and the activity was not inhibited by antibodies capable of neutralizing E. coli CNF type 1. The nucleotide sequence of the Yersinia cnf gene was 65.1% identical to the E. coli cnf gene.
摘要
来自假结核耶尔森菌的细胞提取物以类似于大肠杆菌细胞毒素坏死因子（CNF）所产生的效应的方式诱导HEp-2细胞多核化。该活性不依赖于耶尔森菌70kb的毒力质粒，并且能够中和大肠杆菌1型CNF的抗体不能抑制该活性。耶尔森菌cnf基因的核苷酸序列与大肠杆菌cnf基因的同源性为65.1%。
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