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Species and strain differences in target organ alkylation and toxicity by 4-ipomeanol. Predictive value of covalent binding in studies of target organ toxicities by reactive metabolites.

作者信息

Dutcher J S, Boyd M R

出版信息

Biochem Pharmacol. 1979 Dec 1;28(23):3367-72. doi: 10.1016/0006-2952(79)90074-1.

DOI:10.1016/0006-2952(79)90074-1
PMID:119540
Abstract
摘要

相似文献

1
Species and strain differences in target organ alkylation and toxicity by 4-ipomeanol. Predictive value of covalent binding in studies of target organ toxicities by reactive metabolites.
Biochem Pharmacol. 1979 Dec 1;28(23):3367-72. doi: 10.1016/0006-2952(79)90074-1.
2
In vivo studies on the relationship between target organ alkylation and the pulmonary toxicity of a chemically reactive metabolite of 4-ipomeanol.关于靶器官烷基化与4-异戊烯醇化学反应性代谢物肺毒性之间关系的体内研究。
J Pharmacol Exp Ther. 1978 Dec;207(3):687-97.
3
Role of metabolic activation in the pathogenesis of chemically induced pulmonary disease: mechanism of action of the lung-toxic furan, 4-ipomeanol.代谢活化在化学诱导的肺部疾病发病机制中的作用：肺毒性呋喃4-异戊烯醇的作用机制
Environ Health Perspect. 1976 Aug;16:127-38. doi: 10.1289/ehp.7616127.
4
Effects of anti-NADPH-cytochrome c reductase and anti-cytochrome b5 antibodies on the hepatic and pulmonary microsomal metabolism and covalent binding of the pulmonary toxin 4-ipomeanol.抗NADPH-细胞色素c还原酶抗体和抗细胞色素b5抗体对肺毒素4-异戊烯醇的肝脏和肺微粒体代谢及共价结合的影响。
Biochem Biophys Res Commun. 1978 Sep 29;84(2):389-95. doi: 10.1016/0006-291x(78)90182-1.
5
Development of tolerance to the pulmonary toxin, 4-ipomeanol.对肺部毒素4-异戊二烯醇的耐受性发展
Toxicology. 1981;19(2):85-100. doi: 10.1016/0300-483x(81)90091-3.
6
Protective role of endogenous pulmonary glutathione and other sulfhydryl compounds against lung damage by alkylating agents. Investigations with 4-ipomeanol in the rat.内源性肺谷胱甘肽及其他巯基化合物对烷基化剂所致肺损伤的保护作用。用4-异亚丙基丙酮对大鼠进行的研究。
Biochem Pharmacol. 1982 Apr 15;31(8):1579-83. doi: 10.1016/0006-2952(82)90383-5.
7
In vitro studies on the metabolic activation of the pulmonary toxin, 4-ipomeanol, by rat lung and liver microsomes.大鼠肺和肝微粒体对肺毒素4-异戊二烯醇代谢激活的体外研究。
J Pharmacol Exp Ther. 1978 Dec;207(3):677-86.
8
Distribution and metabolism of the pulmonary alkylating agent and cytotoxin, 4-ipomeanol, in control and diethylmaleate-treated rats.
Biochem Pharmacol. 1982 Apr 15;31(8):1585-9. doi: 10.1016/0006-2952(82)90384-7.
9
Renal toxicity due to reactive metabolites formed in situ in the kidney: investigations with 4-ipomeanol in the mouse.肾脏中因原位形成的反应性代谢产物导致的肾毒性：用4-异戊烯醇在小鼠身上进行的研究。
J Pharmacol Exp Ther. 1981 Mar;216(3):640-6.
10
Ipomeanol 4-glucuronide, a major urinary metabolite of 4-ipomeanol in the rat.
Drug Metab Dispos. 1982 May-Jun;10(3):264-7.

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Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function.对猿类和人类CYP4B1酶的功能分析揭示了催化功能适应性的进化热点。
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Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol.立体化学对 4-表大麦芽酚生物活化和葡萄糖醛酸化的影响。
J Pharmacol Exp Ther. 2019 Feb;368(2):308-316. doi: 10.1124/jpet.118.249771. Epub 2018 Nov 8.
4
Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity.4-异亚丙基甘油的微粒体氧化和葡萄糖醛酸化的种属差异：与靶器官毒性的关系。
Drug Metab Dispos. 2016 Oct;44(10):1598-602. doi: 10.1124/dmd.116.070003. Epub 2016 Jul 28.
5
Characterization of an Additional Splice Acceptor Site Introduced into CYP4B1 in Hominoidae during Evolution.进化过程中在类人猿中引入CYP4B1的一个额外剪接受体位点的特征分析。
PLoS One. 2015 Sep 10;10(9):e0137110. doi: 10.1371/journal.pone.0137110. eCollection 2015.
6
Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.Cyp4b1 基因敲除小鼠的构建及其在 Ipomeanol 激活和毒性中的作用。
Toxicol Sci. 2013 Aug;134(2):243-50. doi: 10.1093/toxsci/kft123. Epub 2013 Jun 7.
7
Phase II study of 4-ipomeanol, a naturally occurring alkylating furan, in patients with advanced hepatocellular carcinoma.对晚期肝细胞癌患者进行的4-异戊烯醇（一种天然存在的烷基化呋喃）的II期研究。
Invest New Drugs. 2001;19(1):69-76. doi: 10.1023/a:1006408803734.
8
Acute effects of 4-ipomeanol on experimental lung tumors with bronchiolar or alveolar cell features in Syrian hamsters or C3H/HeNCr mice.4-异亚丙基莽草酸对叙利亚仓鼠或C3H/HeNCr小鼠具有细支气管或肺泡细胞特征的实验性肺肿瘤的急性影响。
J Cancer Res Clin Oncol. 1993;120(1-2):41-50. doi: 10.1007/BF01200723.
9
Pulmonary endothelial and bronchiolar epithelial lesions induced by 4-ipomeanol in mice.4-异亚丙基丙酮对小鼠肺部内皮细胞和细支气管上皮细胞的损伤
Am J Pathol. 1985 Jan;118(1):66-75.