Monma-Ohtaki Jun, Maeno Yoshitaka, Nagao Masataka, Iwasa Mineo, Koyama Hiroyoshi, Isobe Ichiro, Seko-Nakamura Yoshimi, Tsuchimochi Tsukasa, Matsumoto Tomohiro
Department of Legal Medicine, Nagoya City University Medical School, Kawasumi 1, Mizuho-ku 467-8601, Nagoya, Japan.
Forensic Sci Int. 2002 Mar 28;126(1):77-81. doi: 10.1016/s0379-0738(02)00024-5.
A 65-year-old male patient who was hospitalized with schizophrenia died about 15 min later after ingestion of a large volume of saponated cresol solution in a mental hospital. Fatal levels of free p- and m-cresol in the heart blood were detected at 458.8 and 957.3 microg/ml, respectively, which far exceeded the fatal levels determined previously. The levels in the heart muscle, liver and spleen tissues were also extremely high, and there was 250 ml of cresol-odor-emitting fluid in the stomach. The levels of glucuronic-acid-conjugated p- and m-cresols in the heart blood were 38.2 and 85.6 microg/ml, respectively. Although the high levels of cresols in the heart blood may be due to diffusion from the stomach contents, it is surmised that the essential levels of free and conjugated forms in blood were at least 99 and 240 microg/ml, respectively, considering the results of postmortem examinations and some case reports. It was concluded that about 340 microg/ml of the total cresols was absorbed in a very short period following oral ingestion of saponated cresol solution in this case.
一名65岁男性精神分裂症患者在一家精神病院大量摄入皂化甲酚溶液后约15分钟死亡。心血中游离对甲酚和间甲酚的致死浓度分别检测到458.8和957.3微克/毫升，远远超过先前确定的致死浓度。心肌、肝脏和脾脏组织中的浓度也极高，胃中有250毫升散发甲酚气味的液体。心血中葡萄糖醛酸结合的对甲酚和间甲酚浓度分别为38.2和85.6微克/毫升。尽管心血中甲酚的高浓度可能是由于胃内容物的扩散，但根据尸检结果和一些病例报告推测，血液中游离和结合形式的基本浓度分别至少为99和240微克/毫升。得出的结论是，在该病例中，口服皂化甲酚溶液后在很短时间内约340微克/毫升的总甲酚被吸收。
