Boatto G, Nieddu M, Carta A, Pau A, Lorenzoni S, Manconi P, Serra D
Dipartimento Farmaco Chimico Tossicologico, Università degli Studi di Sassari, Sassari, Italy.
Forensic Sci Int. 2004 Jan 28;139(2-3):191-4. doi: 10.1016/j.forsciint.2003.10.023.
A fatality due to the ingestion of solution containing phenol and o-cresol is described. The pathological findings were typical of acute substantial poisoning. Blood, urine and stomach content were obtained during post mortem examinations. Phenol and o-cresol were identified using GC/MS. The extractions from autopsy materials were obtained as follows: by gel permeation with cyclohexane/dichloromethane from stomach content, by solid phase extraction (SPE) from urine and by deproteinization with acetonitrile from blood. The phenol and o-cresol concentrations in the samples were found, respectively, as follows: 115.0 and 5.0 microg/g in the stomach contents, 58.3 and 1.9 microg/ml in the blood, 3.3 and 20.5 microg/ml in the urine. Distributions of phenol in fatal poisonings have been reported, but, usually, colorimetry was used as the analytical method and it cannot exclude the interference of other phenolic compounds.
本文描述了一起因摄入含苯酚和邻甲酚的溶液而导致的死亡案例。病理检查结果显示为典型的急性实质性中毒。尸检过程中采集了血液、尿液和胃内容物样本。采用气相色谱/质谱联用（GC/MS）技术对苯酚和邻甲酚进行了鉴定。尸检材料的提取方法如下：胃内容物采用环己烷/二氯甲烷凝胶渗透法提取，尿液采用固相萃取法（SPE）提取，血液采用乙腈去蛋白法提取。样本中苯酚和邻甲酚的浓度分别如下：胃内容物中为115.0微克/克和5.0微克/克，血液中为58.3微克/毫升和1.9微克/毫升，尿液中为3.3微克/毫升和20.5微克/毫升。已有关于苯酚在致命中毒案例中分布情况的报道，但通常采用比色法作为分析方法，该方法无法排除其他酚类化合物的干扰。
