Mewasingh Leena D, Sékhara Tayeb, Dachy Bernard, Djeunang Maurice C, Dan Bernard
Department of Neurology, Hôpital Universitaire des Enfants Reine Fabiola, 1020, Brussels, Belgium.
Pediatr Neurol. 2002 Mar;26(3):228-30. doi: 10.1016/s0887-8994(01)00362-9.
Acute ocular paresis, nausea, vomiting, and headaches associated with high intracranial pressure without obvious intracranial pathology are typical features of benign intracranial hypertension. We describe two young children whose presentation, initially suggestive of idiopathic or benign intracranial hypertension, evolved to comprise ophthalmoplegia, ataxia, and areflexia. This triad characterizes Miller Fisher syndrome, a clinical variant of Guillain-Barré syndrome that occurs rarely among children. In both patients, this diagnosis was supported by the clinical course and neurophysiologic findings. Plasma serology was positive for Campylobacter jejuni and anti-GQ1b antibodies in one patient and for antimyelin antibodies in the other. This report of two children with Miller Fisher syndrome presenting with intracranial hypertension adds to the findings for a similar patient treated previously, which raises the question concerning the possible role or contribution of benign intracranial hypertension in Miller Fisher syndrome.
急性眼肌麻痹、恶心、呕吐以及伴有颅内压升高但无明显颅内病变的头痛是良性颅内高压的典型特征。我们描述了两名幼儿，其最初表现提示特发性或良性颅内高压，随后发展为眼肌麻痹、共济失调和反射消失。这三联征是米勒·费希尔综合征的特征，它是吉兰 - 巴雷综合征的一种临床变异型，在儿童中很少见。在这两名患者中，该诊断均得到临床病程和神经生理学检查结果的支持。一名患者的血浆血清学检测显示空肠弯曲菌和抗 GQ1b 抗体呈阳性，另一名患者则是抗髓磷脂抗体呈阳性。这例关于两名患有米勒·费希尔综合征且伴有颅内高压的儿童的报告，补充了之前对一名类似患者的研究结果，这就引发了关于良性颅内高压在米勒·费希尔综合征中可能扮演的角色或作用的问题。
