Kontoyiannis D P, Bodey G P
Department of Infectious Diseases, Infection Control and Employee Health, Box 402, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Eur J Clin Microbiol Infect Dis. 2002 Mar;21(3):161-72. doi: 10.1007/s10096-002-0699-z. Epub 2002 Mar 22.
Despite significant advances in the management of immunosuppressed patients, invasive aspergillosis remains an important life-threatening complication. In the past two decades, the incidence of invasive aspergillosis in this population has continued to increase. Factors that predispose patients to develop invasive aspergillosis include prolonged granulocytopenia, the development of graft-versus-host disease, immunosuppressive therapy, the use of adrenal corticosteroids, and the prolonged impairment of host defenses associated with diseases such as chronic granulomatous disease. Environmental factors also play a key part in the pathogenesis of this infection, and therefore, infection control measures play a critical role in reducing exposure of patients to Aspergillus. New exciting developments in the early diagnosis of invasive aspergillosis and the acceleration of antifungal drug discovery offer promise for the future.
尽管在免疫抑制患者的管理方面取得了重大进展，但侵袭性曲霉病仍然是一种重要的危及生命的并发症。在过去二十年中，该人群中侵袭性曲霉病的发病率持续上升。使患者易患侵袭性曲霉病的因素包括长期粒细胞减少、移植物抗宿主病的发生、免疫抑制治疗、肾上腺皮质类固醇的使用以及与慢性肉芽肿病等疾病相关的宿主防御功能长期受损。环境因素在这种感染的发病机制中也起着关键作用，因此，感染控制措施在减少患者接触曲霉菌方面起着至关重要的作用。侵袭性曲霉病早期诊断和抗真菌药物研发加速方面令人兴奋的新进展为未来带来了希望。
