希腊一家医院新生儿重症监护病房中，阴沟肠杆菌产生与整合子相关的β-内酰胺酶IBC-1引发的感染暴发。
Outbreak of infections caused by Enterobacter cloacae producing the integron-associated beta-lactamase IBC-1 in a neonatal intensive care unit of a Greek hospital.
作者信息
Kartali Georgia, Tzelepi Eva, Pournaras Spyros, Kontopoulou Constantina, Kontos Fanourios, Sofianou Danai, Maniatis Antonios N, Tsakris Athanassios
机构信息
Department of Microbiology, Hippokration General Hospital, Thessaloniki, Greece.
出版信息
Antimicrob Agents Chemother. 2002 May;46(5):1577-80. doi: 10.1128/AAC.46.5.1577-1580.2002.
Abstract
Nineteen of 27 ceftazidime-resistant Enterobacter cloacae isolates from a neonatal intensive care unit in Thessaloniki, Greece, had genes coding for the novel extended-spectrum beta-lactamase IBC-1; 18 of those 19 harbored similar conjugative plasmids and belonged to two distinct genetic lineages. A synergy test with ceftazidime and imipenem enabled us to identify five unrelated bla(IBC-1)-carrying E. cloacae isolates from other wards of the hospital. It seems that this integron-associated gene is capable of dispersing both by clonal spread and by gene dissemination.
摘要
从希腊塞萨洛尼基一家新生儿重症监护病房分离出的27株对头孢他啶耐药的阴沟肠杆菌中，有19株带有编码新型超广谱β-内酰胺酶IBC-1的基因；这19株中的18株携带相似的接合质粒，且属于两个不同的基因谱系。头孢他啶与亚胺培南的协同试验使我们能够从医院其他病房鉴定出5株携带bla(IBC-1)的不相关阴沟肠杆菌分离株。看来这种与整合子相关的基因能够通过克隆传播和基因扩散两种方式传播。
相似文献
1
Outbreak of infections caused by Enterobacter cloacae producing the integron-associated beta-lactamase IBC-1 in a neonatal intensive care unit of a Greek hospital.希腊一家医院新生儿重症监护病房中，阴沟肠杆菌产生与整合子相关的β-内酰胺酶IBC-1引发的感染暴发。
Antimicrob Agents Chemother. 2002 May;46(5):1577-80. doi: 10.1128/AAC.46.5.1577-1580.2002.
2
Monoclonal outbreak of VIM-1-carbapenemase-producing Enterobacter cloacae in intensive care unit, University Hospital Centre Split, Croatia.克罗地亚斯普利特大学医院中心重症监护病房产VIM-1碳青霉烯酶阴沟肠杆菌的单克隆暴发。
Microb Drug Resist. 2014 Oct;20(5):399-403. doi: 10.1089/mdr.2013.0203. Epub 2014 Apr 9.
3
Emergence of VIM-4- and SHV-12-producing Enterobacter cloacae in a neonatal intensive care unit.产 VIM-4 和 SHV-12 的阴沟肠杆菌在新生儿重症监护病房中的出现。
Int J Med Microbiol. 2012 Nov;302(6):257-60. doi: 10.1016/j.ijmm.2012.05.003. Epub 2012 Jun 20.
4
Outbreak of infection caused by Enterobacter cloacae producing the novel VEB-3 beta-lactamase in China.中国产新型VEB-3β-内酰胺酶的阴沟肠杆菌引起的感染暴发
J Clin Microbiol. 2005 Feb;43(2):826-31. doi: 10.1128/JCM.43.2.826-831.2005.
5
Transmission and characterization of bla in Enterobacter cloacae at a teaching hospital in Yunnan, China.中国云南某教学医院阴沟肠杆菌中bla的传播与特征分析
Ann Clin Microbiol Antimicrob. 2017 Aug 22;16(1):58. doi: 10.1186/s12941-017-0232-y.
6
Outbreak of multidrug-resistant CTX-M-15-producing Enterobacter cloacae in a neonatal intensive care unit.产 CTX-M-15 耐药肠杆菌科在新生儿重症监护病房的爆发。
J Med Microbiol. 2013 Apr;62(Pt 4):571-575. doi: 10.1099/jmm.0.053017-0. Epub 2012 Dec 21.
7
Gene mutations responsible for overexpression of AmpC beta-lactamase in some clinical isolates of Enterobacter cloacae.导致阴沟肠杆菌某些临床分离株中AmpCβ-内酰胺酶过表达的基因突变。
J Clin Microbiol. 2005 Jun;43(6):2955-8. doi: 10.1128/JCM.43.6.2955-2958.2005.
8
Prevalence and characterization of extended spectrum beta-lactamase-producing Enterobacter cloacae strains in Algeria.阿尔及利亚产超广谱β-内酰胺酶阴沟肠杆菌菌株的流行情况及特征
J Infect Dev Ctries. 2013 Nov 15;7(11):804-11. doi: 10.3855/jidc.3127.
9
Characterisation and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan.从台湾某地区教学医院分离出的产超广谱β-内酰胺酶阴沟肠杆菌的特征及分子流行病学研究
Clin Microbiol Infect. 2006 Jun;12(6):579-82. doi: 10.1111/j.1469-0691.2006.01384.x.
10
SHV-12 extended spectrum beta-lactamase associated with high-level ceftazidime resistance in Enterobacter cloacae isolated from Thailand.与从泰国分离出的阴沟肠杆菌中高水平头孢他啶耐药性相关的SHV-12超广谱β-内酰胺酶
Southeast Asian J Trop Med Public Health. 2009 Jan;40(1):148-54.
引用本文的文献
1
Association of Novel Nonsynonymous Single Nucleotide Polymorphisms in ampD with Cephalosporin Resistance and Phylogenetic Variations in ampC, ampR, ompF, and ompC in Enterobacter cloacae Isolates That Are Highly Resistant to Carbapenems.阴沟肠杆菌分离株中ampD基因新型非同义单核苷酸多态性与对碳青霉烯类高度耐药的阴沟肠杆菌分离株中头孢菌素耐药性以及ampC、ampR、ompF和ompC基因系统发育变异的关联
Antimicrob Agents Chemother. 2016 Mar 25;60(4):2383-90. doi: 10.1128/AAC.02835-15. Print 2016 Apr.
2
Subtractive hybridization yields a silver resistance determinant unique to nosocomial pathogens in the Enterobacter cloacae complex.减法杂交产生一种独特的针对肠杆菌科中医院病原体的银抗性决定簇。
J Clin Microbiol. 2012 Oct;50(10):3249-57. doi: 10.1128/JCM.00885-12. Epub 2012 Jul 25.
3
Emergence in Spain of a multidrug-resistant Enterobacter cloacae clinical isolate producing SFO-1 extended-spectrum beta-lactamase.西班牙出现一株产 SFO-1 型超广谱β-内酰胺酶的多重耐药阴沟肠杆菌临床分离株。
J Clin Microbiol. 2011 Mar;49(3):822-8. doi: 10.1128/JCM.01872-10. Epub 2011 Jan 12.
4
Colonization and persistence of antibiotic-resistant Enterobacteriaceae strains in infants nursed in two neonatal intensive care units in East London, United Kingdom.英国东伦敦两个新生儿重症监护病房中接受护理的婴儿体内耐抗生素肠杆菌科菌株的定植与持续存在情况。
J Clin Microbiol. 2008 Feb;46(2):560-7. doi: 10.1128/JCM.00832-07. Epub 2007 Nov 26.
5
Carbapenemases: the versatile beta-lactamases.碳青霉烯酶：多功能β-内酰胺酶
Clin Microbiol Rev. 2007 Jul;20(3):440-58, table of contents. doi: 10.1128/CMR.00001-07.
6
Nosocomial outbreak due to extended-spectrum-beta-lactamase- producing Enterobacter cloacae in a cardiothoracic intensive care unit.心胸重症监护病房中由产超广谱β-内酰胺酶的阴沟肠杆菌引起的医院感染暴发。
J Clin Microbiol. 2007 Aug;45(8):2365-9. doi: 10.1128/JCM.02546-06. Epub 2007 Jun 20.
7
Extended-spectrum beta-lactamases: a clinical update.超广谱β-内酰胺酶：临床最新进展
Clin Microbiol Rev. 2005 Oct;18(4):657-86. doi: 10.1128/CMR.18.4.657-686.2005.
8
SHV-type extended-spectrum beta-lactamase production is associated with Reduced cefepime susceptibility in Enterobacter cloacae.产超广谱β-内酰胺酶的SHV型与阴沟肠杆菌对头孢吡肟敏感性降低有关。
J Clin Microbiol. 2005 Oct;43(10):5058-64. doi: 10.1128/JCM.43.10.5058-5064.2005.
9
Extended-spectrum beta-lactamases among Enterobacter isolates obtained in Tel Aviv, Israel.在以色列特拉维夫分离出的肠杆菌中检测到的超广谱β-内酰胺酶
Antimicrob Agents Chemother. 2005 Mar;49(3):1150-6. doi: 10.1128/AAC.49.3.1150-1156.2005.
10
Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.一种能水解头孢西丁且对抑制剂耐药的A类β-内酰胺酶GES-4的分子特征，其ω-环中存在单个G170S取代。
Antimicrob Agents Chemother. 2004 Aug;48(8):2905-10. doi: 10.1128/AAC.48.8.2905-2910.2004.
本文引用的文献
1
Increase of Enterobacter in neonatal sepsis: a twenty-two-year study.新生儿败血症中肠杆菌的增加：一项为期22年的研究。
Pediatr Infect Dis J. 2001 Feb;20(2):134-40. doi: 10.1097/00006454-200102000-00003.
2
IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain.IBC-1，一种由阴沟肠杆菌临床菌株产生的具有超广谱特性的新型整合子相关A类β-内酰胺酶。
Antimicrob Agents Chemother. 2000 Sep;44(9):2247-53. doi: 10.1128/AAC.44.9.2247-2253.2000.
3
4
Detection and reporting of organisms producing extended-spectrum beta-lactamases: survey of laboratories in Connecticut.产超广谱β-内酰胺酶微生物的检测与报告：康涅狄格州实验室调查
J Clin Microbiol. 1999 Dec;37(12):4065-70. doi: 10.1128/JCM.37.12.4065-4070.1999.
5
Control of an outbreak of a highly beta-lactam-resistant Enterobacter cloacae strain in a neonatal special care unit.新生儿重症监护病房中一株对β-内酰胺高度耐药的阴沟肠杆菌菌株暴发的控制
Acta Paediatr. 1998 Oct;87(10):1070-4. doi: 10.1080/080352598750031400.
6
Molecular epidemiological study of nosocomial Enterobacter aerogenes isolates in a Belgian hospital.比利时一家医院院内产气肠杆菌分离株的分子流行病学研究
J Clin Microbiol. 1998 Jul;36(7):1846-52. doi: 10.1128/JCM.36.7.1846-1852.1998.
7
Inducible amp C beta-lactamase producing gram-negative bacilli from blood stream infections: frequency, antimicrobial susceptibility, and molecular epidemiology in a national surveillance program (SCOPE).血流感染中产诱导型AmpCβ-内酰胺酶的革兰氏阴性杆菌：一项全国性监测项目（SCOPE）中的发生率、抗菌药物敏感性及分子流行病学
Diagn Microbiol Infect Dis. 1997 Aug;28(4):211-9. doi: 10.1016/s0732-8893(97)00064-3.
8
Occurrence and detection of extended-spectrum beta-lactamases in members of the family Enterobacteriaceae at a veterans medical center: seek and you may find.退伍军人医疗中心肠杆菌科细菌中广谱β-内酰胺酶的发生与检测：寻则可得。
J Clin Microbiol. 1997 Oct;35(10):2593-7. doi: 10.1128/jcm.35.10.2593-2597.1997.
9
Enterobacter spp.: pathogens poised to flourish at the turn of the century.肠杆菌属：即将在世纪之交蓬勃发展的病原体。
Clin Microbiol Rev. 1997 Apr;10(2):220-41. doi: 10.1128/CMR.10.2.220.
10
Epidemiological typing of isolates from an outbreak of infection with multidrug-resistant Enterobacter cloacae by repetitive extragenic palindromic unit b1-primed PCR and pulsed-field gel electrophoresis.采用重复基因外回文序列b1引物PCR和脉冲场凝胶电泳对多重耐药阴沟肠杆菌感染暴发分离株进行流行病学分型
J Clin Microbiol. 1996 Nov;34(11):2784-90. doi: 10.1128/jcm.34.11.2784-2790.1996.
Zotero 插件