Damen J J M, Buijs M J, ten Cate J M
Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry Amsterdam (ACTA), The Netherlands.
Caries Res. 2002 Jan-Feb;36(1):53-7. doi: 10.1159/000057591.
Caries and gingivitis prevention may benefit from chemotherapeutic plaque control, therefore we compared in a cross-over study with 5 subjects the anti-acidogenic effects of a single use of AmF-SnF2 mouthrinse solutions (Meridol with and without 5% alcohol) with baseline and with the effects of a placebo and a chlorhexidine mouthrinse (CHX). Buccal plaque was collected 0.5, 3 and 8 h after the subjects used one of the mouthrinses, each time before and after a rinse with 10% sucrose to induce lactic acid production. Samples were analysed for acid anions by capillary electrophoresis and for protein. At 0.5 h after the use of AmF-SnF2 or CHX, the concentration of acetate in resting plaque was 70% lower than at baseline or after using the placebo. Average post-sucrose acetate and lactate concentrations in the placebo group were 30-80% higher than at baseline; up to 3 h this difference was significant. 8 h after using AmF-SnF2 or CHX, the post-sucrose acetate and lactate concentrations were still 30-50% lower than after the placebo, and up to 40% lower than at baseline. To conclude, AmF-SnF2 in both Meridol formulations and CHX were shown to have a similar potency to inhibit acid production after a single rinse.
龋齿和牙龈炎的预防可能得益于化学疗法控制牙菌斑，因此我们在一项有5名受试者参与的交叉研究中，比较了单次使用含胺氟-氟化亚锡漱口水溶液（含5%酒精和不含5%酒精的美利道）与基线水平相比、与安慰剂以及洗必泰漱口水（CHX）的抗产酸效果。在受试者使用其中一种漱口水后0.5、3和8小时收集颊部牙菌斑，每次在使用10%蔗糖漱口以诱导乳酸产生之前和之后进行收集。通过毛细管电泳分析样品中的酸性阴离子和蛋白质。在使用胺氟-氟化亚锡或洗必泰后0.5小时，静止牙菌斑中乙酸盐的浓度比基线水平或使用安慰剂后低70%。安慰剂组中蔗糖刺激后的乙酸盐和乳酸盐平均浓度比基线水平高30%-80%；在长达3小时内，这种差异具有统计学意义。在使用胺氟-氟化亚锡或洗必泰后8小时，蔗糖刺激后的乙酸盐和乳酸盐浓度仍比使用安慰剂后低30%-50%，比基线水平低40%。总之，两种美利道配方中的胺氟-氟化亚锡和洗必泰在单次漱口后显示出类似的抑制产酸能力。
