Zhang Y, Zhong N, Zhu H F, Zhou Z N
Shanghai Institute of Physiology, Chinese Academy of Sciences Shanghai 200031.
Sheng Li Xue Bao. 2000 Apr;52(2):89-92.
The purpose of the study was to observe the effects of intermittent hypoxia exposure (IH) on the arrhythmia and antioxidation with ligation of coronary artery of rat heart together with measuring SOD (superoxide dismutase) and MDA (malondialdehyde) in myocardium. Comparison with continued hypoxia exposure was also made. The results obtained are as follows. (1) Arrhythmia scores of ischemic arrhythmia and reperfusion arrhythmia observed in the rats treated with IH 28-day (IH28) and 42-day (IH42), one week (IH28-1W) and two weeks (IH28-2W) after 28-day IH, as well as in those with continued hypoxia 28-day (CH28) and 42-day (CH42), were significantly lower than controls. (2) SOD in IH28, IH42, CH28, CH42, IH28-1W, IH28-2W and three weeks after 28-day IH were significantly higher than controls; MDA in IH14, IH28, IH42, CH28, CH42, IH28-1W and IH28-2W were significantly lower than controls. It is suggested that IH for 28 or 42 days has some definite antiarrhythmic effect against ischemia and reperfusion, which was related to the strength of antioxidation in myocardium. The antiarrhythmic effects occurred gradually after 14 days IH and persisted for about two weeks after 28 days IH.
本研究的目的是观察间歇性低氧暴露（IH）对大鼠心脏冠状动脉结扎所致心律失常及抗氧化作用的影响，并检测心肌中超氧化物歧化酶（SOD）和丙二醛（MDA）的含量。同时与持续低氧暴露进行比较。结果如下：（1）接受28天（IH28）和42天（IH42）间歇性低氧处理的大鼠，在28天间歇性低氧处理后1周（IH28 - 1W）和2周（IH28 - 2W）时，以及接受28天（CH28）和42天（CH42）持续低氧处理的大鼠，其缺血性心律失常和再灌注性心律失常的心律失常评分均显著低于对照组。（2）IH28、IH42、CH28、CH42、IH28 - 1W、IH28 - 2W组以及28天间歇性低氧处理后3周时的SOD含量均显著高于对照组；IH14、IH28、IH42、CH28、CH42、IH28 - 1W和IH28 - 2W组的MDA含量均显著低于对照组。提示28天或42天的间歇性低氧暴露对缺血和再灌注具有一定的抗心律失常作用，这与心肌抗氧化能力的增强有关。间歇性低氧暴露14天后抗心律失常作用逐渐显现，28天间歇性低氧暴露后持续约两周。
