Wu K K, Hoak J C, Thompson J S, Koepke J A
N Engl J Med. 1975 Jan 16;292(3):130-3. doi: 10.1056/NEJM197501162920303.
To determine if platelet aggregometry was useful in selecting compatible platelet donors, six patients who had become refractory to random platelets were studied. Serum from the patient was added to citrated platelet-rich plasma from the prospective donor in a standard aggregometry system. Serial aggregometry studies revealed no platelet aggregation unless the refractory state had been reached. At that time positive aggregation occurred only between the poorly matched pairs. A correlation between platelet aggregation and HL-A histocompatibility was noted. Family members with negative aggregation were selected as donors, and their platelets were able to provide consistently satisfactory increments in the platelet count of the recipient who was refractory to random donors. In contrast, platelets from family members who exhibited positive aggregation failed to do so. These findings suggest that platelet aggregometry can be used to select compatible platelet donors.
为了确定血小板聚集试验是否有助于选择相容的血小板供体，对6例对随机供体血小板产生不应性的患者进行了研究。在标准的血小板聚集试验系统中，将患者的血清加入到来自预期供体的枸橼酸化富血小板血浆中。系列血小板聚集试验显示，除非达到不应性状态，否则不会出现血小板聚集。在达到不应性状态时，只有不相容的供受者对之间才会出现阳性聚集。发现血小板聚集与HL - A组织相容性之间存在相关性。聚集试验呈阴性的家庭成员被选为供体，他们的血小板能够使对随机供体不应性的受者的血小板计数持续得到满意的增加。相反，聚集试验呈阳性的家庭成员的血小板则不能。这些发现表明，血小板聚集试验可用于选择相容的血小板供体。
